UNIT 4: Cell Communication & Cell Cycle   Riedell Cells webpage    Riedell AP BIO Cell Division webpage   9-11 Class Periods    Exam Weight 10-15%

1-EVO Evolution
2-ENE Energetics
3-IST Information Storage and Transmission
4-SYI Systems Interactions
SP1 Concept Explanations
SP2 Visual Representations
SP3 Questions and Methods
SP4 Representing and Describing Data
SP5 Statistical Tests and Data Analysis
SP6 Argumentation

PowerPoints Videos LABS/Activities BILL videos/Activities

The Cell Cycle

IST 1.E.1; ENE 1.B.2



Bozeman videos 1.B;1.C;
Phases of Mitosis 
Phases of Meiosis

Meiosis Lab

Bozeman Mitosis Phases   Google Docs quiz 


Desktop Mitosis cards   IST 1.B;1.C;

Modeling mitosis with yarn  IST 1.B;1.C;

LAB 7:Modeling Mitosis/Meiosis with Pop beads IST 1.B;1.C;

LAB 7: Mitosis/Meiosis Lab  IST 1.B;1.C;
Sordaria lab    LAB PIX


Interphase study guide 
Check answers
IST 1.B.2; 1.D. 1 & 2 

Mitosis study guide  
Check answers  

IST 1.B.2

BILL reverse prophase ? 1.B;1.C;

BILL mitosis roles ? 1.B;1.C;

BILL-SA/VOL Think about it ?'s 

BILL genetic variation 

Mitosis/Meiosis Comparison
IST 1.B.1; 1.C.1; 1.G

Bozeman Videos
IST 3.A; 3.B;3.C; 3.E; 3.F

Cell Communication 

Signal transmission & Gene expression

Signal transduction pathways
Effects of Changes in Pathways 

Homeostatic Loops  ENE 3.A.1
Homeostasis Hugs   ENE 3.A.1
Countercurrent flow  ENE 3.A.1

Positive & Negative Feedback loops
ENE 3.B.1; ENE 3.C.1

Youtube videos
IST 3.A; 3.B;3.C; 3.E; 3.F

Tyrosine kinase
Intracellular receptors
Ligand gated ion channel
Phosphorylation cascade
Watch 2:44-3:16
Tyrosine Kinase
cyclic AMP (cAMP)
G proteins

Quorum sensing example
IST 3.E; 3.F
Bonnie Bassler-How  bacteria "talk"- 18 min

Bessler-short version 6 min 

Quorum sensing 3:48 min



POGIL-Cell Communication  
IST 3.A & 3.B; IST E.1

Cell Communication BILL notes 
IST 3.A & 3.B; IST E.1

BILL Cell signaling comparison
 IST 3.A & 3.B; IST E.1
  Past FRQs
Cell division cartoons
Cells,Transport, & Signaling
Mitosis/Meiosis Kahoot
Mitosis/Meiosis Card Review 
Mitosis/Meiosis Clicker review w/answers

Bozeman Unit 4 Review- Homeostasis


LO/EK description  
IST 3.A Describe the ways that cells can communicate with one another.  
IST 3.A.1 Cells communicate with one another through direct contact with other cells or from a distance via chemical signaling—
a. Cells communicate by cell-to-cell contact.
POGIL-Cell Communication
IST 3.B Explain how cells communicate with one another over short and long distances.  
IST 3.B.1 Cells communicate over short distances by using local regulators that target cells in the vicinity of the signal-emitting cell —
   a. Signals released by one cell type can travel long distances to target cells of another
        cell type.
POGIL-Cell Communication
IST 3.C Describe the components of a signal transduction pathway.  
IST 3.C.1 Signal transduction pathways link signal reception with cellular responses. MODELING SIGNAL TRANSDUCTION PATHWAYS
IST 3.C.2 Many signal transduction pathways include protein modification and phosphorylation cascades.
IST 3.D Describe the role of components of a signal transduction pathway in producing a cellular response.  
IST 3.D.1 Signaling begins with the recognition of a chemical messenger—a ligand—by a receptor protein in a target cell—
   a. The ligand-binding domain of a receptor recognizes a specific chemical messenger,   
       which can be a peptide, a small chemical, or protein, in a specific one-to-one
   b. G protein-coupled receptors are an example of a receptor protein in eukaryotes.
IST 3.D.2 Signaling cascades relay signals from receptors to cell targets, often amplifying the incoming signals, resulting in the appropriate responses by the cell, which could include cell growth, secretion of molecules, or gene expression—
    a. After the ligand binds, the intracellular domain of a receptor protein changes shape
        initiating transduction of the signal.
     b. Second messengers (such as cyclic AMP) are molecules that relay and amplify the
            intracellular signal.
     c. Binding of ligand-to-ligand-gated channels can cause the channel to open or close.
IST 3.E Describe the role of the environment in eliciting a cellular response.  
IST E.1 Signal transduction pathways influence how the cell responds to its environment POGIL-Cell Communication

BILL Cell signaling comparison
IST 3.F Describe the different types of cellular responses elicited by a signal transduction pathway.  
IST 3.F.1 Signal transduction may result in changes in gene expression and cell function, which may alter phenotype or result in programmed cell death (apoptosis). MODELING SIGNAL TRANSDUCTION PATHWAYS
BILL Cell signaling comparison
IST 3.G Explain how a change in the structure of any signaling molecule affects the activity of the signaling pathway.  
IST 3.G.1 Changes in signal transduction pathways can alter cellular response—
a. Mutations in any domain of the receptor protein or in any component of the signaling pathway may affect the downstream components by altering the subsequent transduction of the signal.
Effects of Changes in Pathways
IST 3.G.2 Chemicals that interfere with any component of the signaling pathway may activate or inhibit the pathway.
ENE 3.A Describe positive and/ or negative feedback mechanisms.  
ENE 3.A.1 Organisms use feedback mechanisms to maintain their internal environments and respond to internal and external environmental changes. Homeostatic Loops
Homeostasis Hugs
ENE 3.B Explain how negative feedback helps to maintain homeostasis.  
ENE 3.B.1 Negative feedback mechanisms maintain homeostasis for a particular condition by regulating physiological processes. If a system is perturbed, negative feedback mechanisms return the system back to its target set point. These processes operate at the molecular and cellular levels. Positive & Negative Feedback loops
ENE 3.C Explain how positive feedback affects homeostasis.  
ENE 3.C.1 Positive feedback mechanisms amplify responses and processes in biological organisms. The variable initiating the response is moved farther away from the initial set point. Amplification occurs when the stimulus is further activated, which, in turn, initiates an additional response that produces system change. Positive & Negative Feedback loops
IST 1.B Describe the events that occur in the cell cycle.  
IST 1.B.1 In eukaryotes, cells divide and transmit genetic information via two highly regulated processes. Mitosis/Meiosis Comparison
IST 1.B.2 The cell cycle is a highly regulated series of events for the growth and reproduction of cells—
a. The cell cycle consists of sequential stages of interphase (G1, S, G2), mitosis, and cytokinesis.
b. A cell can enter a stage (G0) where it no longer divides, but it can reenter the cell cycle in response to appropriate cues. Nondividing cells may exit the cell cycle or be held at a particular stage in the cell cycle.
Regulation powerpoint

Interphase study guide 

Phases of Mitosis

Mitosis phases study guide
IST 1.C Explain how mitosis results in the transmission of chromosomes from one generation to the next.  
IST 1.C.1 Mitosis is a process that ensures the transfer of a complete genome from a parent cell to two genetically identical daughter cells—
a. Mitosis plays a role in growth, tissue repair, and asexual reproduction.
b. Mitosis alternates with interphase in the cell cycle.
c. Mitosis occurs in a sequential series of steps (prophase, metaphase, anaphase, telophase).
Phases of Mitosis

Mitosis phases study guide

Mitosis/Meiosis Comparison
IST 1.D Describe the role of checkpoints in regulating the cell cycle.  
IST 1.D.1 A number of internal controls or checkpoints regulate progression through the cycle. Interphase study guide
IST 1.D.2 Interactions between cyclins and cyclin dependent kinases control the cell cycle.
IST 1.E Describe the effects of disruptions to the cell cycle on the cell or organism.  
IST 1.E.1 Disruptions to the cell cycle may result in cancer and/or programmed cell death (apoptosis). Powerpoint Regulation
    The following learning targets are from the CED for UNIT 5 Heredity  
IST 1.F Explain how meiosis results in the transmission of chromosomes from one generation to the next.  
IST 1.F.1 Meiosis is a process that ensures the formation of haploid gamete cells in sexually reproducing diploid organisms Modeling Mitosis/Meiosis with Pop beads
IST 1.G Describe similarities and/ or differences between the phases and outcomes of mitosis and meiosis.  
IST 1.G.1 Mitosis and meiosis are similar in the way chromosomes segregate but differ in the number of cells produced and the genetic content of the daughter cells. Modeling Mitosis/Meiosis with Pop beads
Mitosis/Meiosis Comparison
IST 1.H Explain how the process of meiosis generates genetic diversity  
IST 1.H.1 Separation of the homologous chromosomes in meiosis I ensures that each gamete receives a haploid (1n) set of chromosomes that comprises both maternal and paternal chromosomes.  Modeling Mitosis/Meiosis with Pop beads
IST 1.H.2 During meiosis I, homologous chromatids exchange genetic material via a process called “crossing over” (recombination), which increases genetic diversity among the resultant gametes.  Crossing over, linked genes, & Gene mapping video
BILL genetic variation 
IST 1.H.3 Sexual reproduction in eukaryotes involving gamete formation—including crossing over, the random assortment of chromosomes during meiosis, and subsequent fertilization of gametes—serves to increase variation. Crossing over, linked genes, & Gene mapping video
BILL genetic variation 


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