UNIT 1:Chemistry of Life          Riedell AP Bio Chemistry of Life webpage      5-7 Class Periods    Exam Weight 8-11%

1-EVO Evolution
2-ENE Energetics
3-IST Information Storage and Transmission
4-SYI Systems Interactions
SP1 Concept Explanations
SP2 Visual Representations
SP3 Questions and Methods
SP4 Representing and Describing Data
SP5 Statistical Tests and Data Analysis
SP6 Argumentation

LABS/Activities BILL videos/Activities
Bozeman Science Chem review videos

Chemistry Background For Biology
by Kristina Gremski
Water Lab
SYI-1.A.1, 1.A.2, 1.A.3
Station #1 video
Station #5 video
Station #8 video
Cup of Water kits modeling

Concord Consortium Hydrogen bonding Water 

Properties of water BILL organizer 
SYI-1.A.1, 1.A.2, 1.A.3

Desktop concept map- MACROMOLECULES 
ENE 1,A;SYI 1.B & 1.C; IST 1.A

Pattern Matching Activity  ENE 1.A; SYI 1.B
 Jennifer Sosnowski 
(adapted from http://www.biologylessons.sdsu.edu/classes/lab6/lab6.html)
Watch video, take notes in your BILL/ answer ?'s in your BILL

Chemistry Background For Biology Kristina Gremski
Bond comparison chart

Bozeman Beginner's guide to graphing data / What makes a good graph ?

Bozeman Scientific method / answer the ?'s 

Bozeman Claim Evidence Reasoning (CER) / Notes

Properties of water poster
Properties of water organizer
SYI 1.A.

Molecules of Life video
ENE 1.A.1; 1.A.2

Functional group video 1
Functional group video 2 

Functional Groups desktop match  Organizer   
Functional group quiz
Bozeman videos
Molecules of Life 
ENE 1.A;SYI 1.B & 1.C; IST 1.A

Biological Molecules
ENE 1.A;SYI 1.B & 1.C; IST 1.A

Crash Course
You are What You Eat
ENE 1.A;SYI 1.B & 1.C; IST 1.A

-Glucose in water

Water A polar molecule   
SYI-1.A.1, 1.A.2, 1.A.3

Water: Liquid Awesome  
SYI-1.A.1, 1.A.2, 1.A.3

Hydrogen bonding animation  SYI 1A

Transpiration   SYI 1A

Amoeba sisters-Properties of water
SYI-1.A.1, 1.A.2, 1.A.3
Water   SYI 1.A.1, 1.A.2, 1.A.3
from Kim Foglia

ENE 1.A;SYI 1.B & 1.C; IST 1.A

Slide show modified from




Powerpoint videos
 ENE 1.A;SYI 1.B & 1.C; IST 1.A

Nucleic acids

Protein folding    SYI 1.C.1

David Knuffke's Prezis
AP Bio- Chemistry 1:   
Atoms, Water, & Carbon
AP Bio- Chemistry 2: Macromolecules
AP Bio- Intro

Glen Wolkenfeld- Science Music Videos
The Four Biomolecule Families 
Biochemistry 1: Monomers and Polymers
Biochemistry 2: Carbohydrates
Biochemistry 3: Lipids
Biochemistry 4-Proteins
Biochemistry 5: Nucleic Acids (overview)
Biochemistry 6: Cumulative Biochemistry Flashcards and Quizzes

Modeling Biomolecules-   SYI-1.B.2
BILL-size mini protein cutouts 
Modified from Kim Foglia Explore Biology

Make a peptide bond  SYI 1.B.2; 1.C.1
Peptide bond formation 
SYI 1.B.2; 1.C.1

Campbell Protein Structure  SYI 1.B.2; 1.C.1
Phospholipid animation   SYI 1.B.2.d
Review games
Click and Go - Powerpoint REVIEW-Chemistry, Carbon, Water, & Molecules

Desktop concept maps      answers

Chemistry of Life Chapter review

AP BIO Chemistry of Life
AP BIO Lipids
AP BIO Proteins
AP BIO Carbs

Chemistry, Carbon, Water, Molecules Desktop Card Review
Check your answers

Glen Wolkenfeld
Biochemistry 6: Cumulative Biochemistry Flashcards and Quizzes
Macromolecules Powerpoint

Watch video

BILL ?'s
Carbs Carb ?'s 
Modified from BIO87/POGIL
SYI 1.B.2.c
SYI 1.C.1.e
Proteins Protein ?'s 
Modified from Holtzclaw/Foglia/Miriello study guides

SYI 1.B.2.b

SYI 1.C.1.c & d
Lipids Lipid ?'s  Modified from Holtzclaw study guide SYI 1.B.2.d
Nucleic acids NUCLEIC ACID ?'s
Modified from Holtzclaw/Foglia/Miriello study guides
SYI 1.B.2.a;
SYI 1.C.1a&b;
IST 1.A.4

3D Molecular Designs amino acid starter kit
TOOBER Protein modeling

Protein folding
SP2; SYI 1.B.2; 1.C.1

Protein folding with party hats 
SP2; SYI 1.B.2; 1.C.1

Water Cartoons
Molecule Cartoons

What's a pirate's favorite amino acid?


LO/EK description  
SYI 1A Explain how the properties of water that result from its polarity and hydrogen bonding affect its biological function. Water Lab
Station #1 video
Station #5 video
Station #8 video

Cup of Water kits modeling

Hydrogen bonding animation

Concord Consortium Hydrogen bonding Water 

  1.A.1 The subcomponents of biological molecules and their sequence determine the properties of that molecule
  1.A.2 Living systems depend on properties of water that result from its polarity and hydrogen bonding
  1.A.3 The hydrogen bonds between water molecules result in cohesion, adhesion and surface tension.
ENE 1.A Describe the composition of macromolecules required by living organisms
ENE 1.A.1 Organisms must exchange matter with the environment to grow, reproduce, and maintain organization.
Molecules of Life video


.ENE 1.A.2 Atoms and molecules from the environment are necessary to build new molecules.
a. Carbon is used to build biological molecules such as carbohydrates, proteins, lipids, and nucleic acids.  Carbon is used in storage compounds and cell formation in all organisms.
b. Nitrogen is used to build proteins and nucleic acids. Phosphorus is used to build nucleic acids and certain lipids.
SYI 1.B Describe the properties of the monomers and the type of bonds that connect the monomers in biological macromolecules.  
SYI 1.B.1 Hydrolysis and dehydration synthesis are used to cleave and form covalent bonds between monomers.
Monomer/polymer game
idea from Mary Garrison Neimeyer

Molecules of Life video
SYI 1.B.2 Structure and function of polymers are derived from the way their monomers are assembled—
a. In nucleic acids, biological information is encoded in sequences of nucleotide monomers. Each nucleotide has structural components: a five-carbon sugar (deoxyribose or ribose), a phosphate, and a nitrogen base (adenine, thymine, guanine, cytosine, or uracil). DNA and RNA differ in structure and functions
Nucleic acids video         BILL NUCLEIC ACID ?'s

Desktop concept map- MACROMOLECULES 
b. In proteins, the specific order of amino acids in a polypeptide (primary structure) determines the overall shape of the protein. Amino acids have directionality, with an amino (NH2) terminus and a carboxyl (COOH) terminus. The R group of an amino acid can be categorized by chemical properties (hydrophobic, hydrophilic, or ionic), and the interactions of these R groups determine structure and function of that region of the protein. Proteins video    BILL Protein ?'s 

3D Molecular Protein folding       Handout  

Protein folding party hats
c. Complex carbohydrates comprise sugar monomers whose structures determine the properties and functions of the molecules. Carbohydrates video         BILL Carb ?'s 

d. Lipids are nonpolar macromolecules—
i. Differences in saturation determine the structure and function of lipids.
ii. Phospholipids contain polar regions that interact with other polar molecules, such as water, and with nonpolar regions that are often hydrophobic.
Lipids video        BILL Lipid ?'s 

Phospholipid animation
SYI 1.C Explain how a change in the subunits of a polymer may lead to changes in structure or function of the macromolecule.  
SYI 1.C.1 Directionality of the subcomponents influences structure and function of the polymer—
a. Nucleic acids have a linear sequence of nucleotides that have ends, defined by the 3’ hydroxyl and 5’ phosphates of the sugar in the nucleotide. During DNA and RNA synthesis, nucleotides are added to the 3’ end of the growing strand, resulting in the formation of a covalent bond between nucleotides.
b. DNA is structured as an antiparallel double helix, with each strand running in opposite 5’ to 3’ orientation. Adenine nucleotides pair with thymine nucleotides via two hydrogen bonds. Cytosine nucleotides pair with guanine nucleotides by three hydrogen bonds.
Nucleic acids VIDEO       BILL NUCLEIC ACID ?'s
c. Proteins comprise linear chains of amino acids, connected by the formation of covalent bonds at the carboxyl terminus of  the growing peptide chain.
d. Proteins have primary structure determined by the sequence order of their constituent  amino acids, secondary structure that arises through local folding of the amino acid chain into elements such as alpha-helices and beta-sheets, tertiary structure that is the overall three-dimensional shape of the protein and often minimizes free energy, and quaternary structure that arises from interactions between multiple polypeptide units. The four elements of protein structure determine the function of a protein.
Proteins video    BILL Protein ?'s 

Make a peptide bond 
Peptide bond formation

Campbell Protein Structure 

Protein folding video

Protein folding with party hats 
e. Carbohydrates comprise linear chains of sugar monomers connected by covalent bonds. Carbohydrate polymers may be linear  or branched.
ILLUSTRATIVE EXAMPLE- Cellulose versus starch versus glycogen
Carbohydrates video         BILL Carb ?'s 
IST 1.A Describe the structural similarities and differences between DNA and RNA.  
IST 1.A.1 DNA and RNA molecules have structural similarities and differences related to their function—
a. Both DNA and RNA have three components—sugar, a phosphate group, and a nitrogenous base—that form nucleotide units that are connected by covalent bonds to form a linear molecule with 5’ and 3’ ends, with the nitrogenous bases perpendicular to the sugar-phosphate backbone.
b. The basic structural differences between DNA and RNA include the following:
i.contains deoxyribose and RNA contains ribose.
ii. RNA contains uracil and DNA contains thymine.
iii. DNA is usually double stranded; RNA is usually single stranded.
iv. The two DNA strands in double-stranded DNA are antiparallel in directionality.
Nucleic acids VIDEO       BILL NUCLEIC ACID ?'s


SYI 3.A Explain the connection between variation in the number and types of molecules within cells to the ability of the organism to survive and/or reproduce in different environments.  
SYI 3.A.1 Variation at the molecular level provides organisms with the ability to respond to a variety of environmental stimuli.  
SYI 3.A.2 Variation in the number and types of molecules within cells provides organisms a greater ability to survive and/or reproduce in different environments.  


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